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Bioencap_Innov_sept_2011.pdf

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September 2011

ÉDITORIAL

THE FUTURE OF ENCAPSULATION TECH-

NOLOGY: THE NEED FOR COLLABORATIVE

RESEARCH TO BREAK FRESH BOUNDARIES

Ian Marison, Dublin City University and National Institute of Bioproces- sing Research and Training, Dublin, Ireland

I have been involved in encapsula- tion technology for over 25 years; consequently this is a form of anni- versary editorial for me! My own work began, by trying to develop high density yeast cell cultures for the production of alcohol from whey fermentations for use as a biofuel. The problem then, and to a considerable degree now, was the lack of systems to produce microcapsules of de ned properties at a scale to enable them to be put into bioreactors, and even the uidized-bed bioreactors necessary to carry out these cultures. Fortunately being in an engineering department in a Swiss university, we had no problem building both with the help of colleagues at the ETH-Zurich. The result was a pro- totype of a vibrating

In addition, the polymer systems still re- present a major limitation to many deve- lopments and applications, since they are often of natural origin and highly variable in composition and properties, which make them dif cult to prepare using the encapsulation devices e.g. variable mo- lecular weight distribution, wide range of viscosities, purity, degree of substitution etc. Indeed synthetic polymers frequent- ly suffer from the same problems!

The applications of encapsulation are far to numerous to list, in an enormous range of areas covering food technology, biomedical, taste- masking, protection of active ingredients, water treatment and many more. In my view however, a lot

nozzle system which

became the basis

for the foundation

of a start-up. There

followed work on

bioarti cial organs,

in particular xeno-

and holo-transplants

of pancreatic islets,

which resulted in the

development of a sterilisable system but still only a single nozzle and limited ow rates.

Many years of research followed and some excellent work was carried out by COST840 and 865 groups to de ne the methods to characterize capsules. However, while excellent equipment has been developed and presented at many of the BRG meetings, the majority are based on classic methods (some of which are described in the article within this news letter) and, although some might disagree, there are still major limitations in the production of microcapsules of de- ned size, certain size ranges, shape and properties at a scale suitable for com- mercial application and under controlled environmental conditions.

of collaborative work has been hampered by the desire to com- mercialise the results which has limited true collaboration between researchers. It is my request that we de ne some of these areas, whether equipment de- sign and development,

polymer production or speci c applica- tions to attack these problems before another 25 years passes- I am certainly open to discussion!

Presently I am the Director of a new research centre in Dublin (NIBRT) and I welcome you all to look up the website (www.nibrt.ie) and visit the centre both virtually and by coming to Dublin for a visit and a Guinness. These industry-like facilities (GMP-compatible) are open for use by all of you, and I would be very keen to set-up an encapsulation laboratory with your support- sabbaticals, second- ments and collaborations are welcome!

Ian Marison

THE PROBLEM ... WAS THE LACK OF SYS- TEMS TO PRODUCE MICROCAPSULES OF DEFINED PROPERTIES

SOMMAIRE

EDITORIAL ............................................. 1 The future of encapsulation

technology

COMING CONFERENCES ......... 2 XIX International Conference on

Bioencapsulation Amboise, France

October 5-8, 2011

COMING CONFERENCES ......... 3 XV Industrial Symposium and VI

trade fair on microencapsulation Archamps/Geneva, France March 20-22, 2012

ARTICLE ................................................... 4 Microencapsulation by Dripping

and Jet break up

COMING CONFERENCES .... 11 South American Symposium on

Microencapsulation Limeira, Brasil

April 30 - May 2, 2012

JOURNAL ISSUES ........................ 12

DIVERSIFIED ...................................... 13

ARTICLE ................................................. 14

Preparing functionalized threads, scaffolds and micro bubbling/foaming with advanced materials

THESIS ...................................................... 15 ARTICLE .................................................. 16

Flow Focusing® Microencapsu- lation: Much More than Dripping

ARTICLE .................................................. 18 Observing a dripping process

ASSOCIATION ..................................20

Bioencapsulation Research Group

1

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 Supercritical Fluid Extraction Bioencap_Innov_sept_2011.pdf Page 001
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