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Process Intensification for Production and Recovery of Biological Products

1Hamideh Vaghari, 1Maryam Eskandari, 1Vahideh Sobhani, 2Aydin Berenjian, 3Yuanda Song and 1Hoda Jafarizadeh-Malmiri

1Department of Chemical Engineering, Sahand University of Technology, Tabriz, Iran

2School of Engineering, Faculty of Science and Engineering, The University of Waikato, Hamilton, New Zealand 3Colin Ratledge Center for Microbial Lipids, School of Agriculture Engineering and Food Science,

Shandong University of Technology, Zibo, Shandong, China

American Journal of Biochemistry and Biotechnology

Article history

Received: 14-01-2015 Revised: 23-01-2015 Accepted: 24-01-2015

Corresponding author:

Aydin Berenjian

School of Engineering, Faculty of Science and Engineering, The University of Waikato, Hamilton, New Zealand



The need for sustainable, efficient and cost effective processes are in demand for many chemical and biological industries (Wohlgemuth, 2009). Several alternatives have been developed to address some of the problems associated with the use of the conventional apparatuses and techniques. Process Intensification (PI) has been known as a method to comply with such requirements (Lutze et al., 2010). Process intensification as a method for making significant changes in the size of a process plants to achieve a given production objective. These reductions can come from decreasing the size of individual equipment or from removing the number of involved unit operations (Stankiewicz and Moulijn, 2000). PI may be defined in a number of ways. One of several definitions of PI sets out a selection of all themes is that “Any chemical engineering development that leads to a substantially smaller, cleaner, safer and more

energy efficient technology is process intensification” (Reay et al., 2013). PI refers to replace complex technologies with integrated equipment and processes that are smaller in size, less costly and more efficient (Charpentier, 2007). Preferably, it integrates as many unit operations as possible into a multifunctional ones to be used in the chemical and biological industries (Marques and Fernandes, 2011). Environmentally, however, the most telling impact of PI is likely to be in the development of reactor designs for truly green technology. It is well understood that the reactor is the heart of any chemical process, as it dictates both the product quality and the extent of the downstream separation and treatment equipment. Designing reactors which operate intensively and which give high conversion and selectivity with minimal by-product formation will permit us to approach the green ideal of delivering a high quality product without an extensive downstream purification sequence. Among the

Abstract: Bioprocesses are important biological reactions which need several sophisticated methods and equipment to produce many novel and important compounds which some of them are traditionally produced by synthetic chemical reactions. In bioprocesses, the products are often produced in a dilute environment and finally they require a high purity. Because of that, downstream processes are usually included a large number of separation steps. Size and capital costs of the equipment are two main limitations of using bioprocesses at industrial scale. Bioprocess intensification by minimizing, substitution, moderation and simplification of the methods and equipment, drastically leads to sustainable processes. This study looks at intensification of the emerging equipment and operational methods and their advantages to lead smaller and cleaner bioprocess plants which in turn, increases production efficiency and quality and decreases byproducts formation, capital cost and energy consumption.

Keywords: Bioprocessing, Intensification, Energy, Equipment Size, Production Capacity

© 2015 Hamideh Vaghari, Maryam Eskandari, Vahideh Sobhani, Aydin Berenjian, Yuanda Song and Hoda Jafarizadeh- Malmiri. This open access article is distributed under a Creative Commons Attribution (CC-BY) 3.0 license.

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